Macrene Actives

It's here. Dr. Macrene's Birthday Event begins today — a rare window to experience our most coveted formulas at an exceptional offer. Luxury doesn't linger, and neither does this celebration. Shop now before it's gone. ✨

Summer sun is beautiful — until it isn't. ☀️

We asked Dr. Macrene how to protect skin now and repair what's already been done. Her answer? A daily ritual, a few smart habits, and formulas that actually work.

Swipe through her full protocol — from SPF timing to the actives that undo damage.

Shop the routine at the link in bio.

Featured in Marie Claire's "The Complete Guide to Leg Vein Treatments," Dr. Macrene shares her expert perspective on the factors that contribute to visible leg veins and the latest treatment options.

We're grateful to Marie Claire for including Dr. Macrene's expertise in this important conversation.

"If we can stimulate our DNA repair molecules, we can at any age restore our skin to optimal health and protect the skin from the damage that causes skin aging and cancer."

— Dr. Macrene

Inspired by decades of Nobel Prize-winning DNA repair research, Dr. Macrene Alexiades developed MA37® Patented Technology to help optimize the delivery of high-performance actives that support visible skin rejuvenation.

Experience MA37® technology in High Performance Face Cream, High Performance Face Serum, and High Performance Tinted Moisturizer.

Join Dr. Macrene at Violet Grey East Hampton on August 7–8 for a personalized one-on-one consultation.

Receive a customized skin analysis, discuss your unique skin concerns and goals, and discover the science behind healthier-looking skin.

Appointments are limited and available by reservation only.

Reserve your spot through the link in today's Stories

Coming Soon! High Performance Broad Spectrum Mineral SPF 50

High Performance Broad Spectrum. Mineral SPF 50 combines broad-spectrum UV protection with clinically advanced skincare in a 100% mineral, lightweight, fragrance-free formula.

Powered by 30 active botanicals, it helps visibly firm, brighten, hydrate, and support the skin barrier while providing antioxidant defense against UV-induced oxidative stress.

Our Broad Spectrum SPF 50 formula helps protect against sunburn and early skin aging when used as directed. Regular use decreases the risk of skin cancer and early skin aging caused by the sun.

Follow along as we share more about High Performance Broad Spectrum Mineral SPF 50 in the weeks ahead.

"I'm focusing 1 million percent of my attention on hands."
— Dr. Macrene

Recently featured in Vanity Fair's "So You Got a Face Lift. What Are You Gonna Do About Your Hands?" article, Dr. Macrene discusses why the hands are often one of the first places to reveal visible signs of aging—and why they deserve the same attention as the face.

In the feature, she shares how fillers, PRF, and laser treatments can help restore a more youthful appearance to this often-overlooked area.

Thank you to Vanity Fair for highlighting this important conversation.

Dr. Macrene believes complexion products should improve skin—not simply cover it.

That's why High Performance Tinted Moisturizer was formulated with clinically advanced skincare actives alongside complexion-enhancing mineral pigments.

Available in six shades, the skin tone-adjusting formula features reflective properties and best-in-class luxury pigments that adapt to a broad range of skin tones.

Peptides, hyaluronic acids, and proline help improve the appearance of fine lines and wrinkles. Glucosamine and amino acids help visibly brighten uneven skin tone. Coffee seed extract, feverfew, and antioxidant-rich botanicals help calm the appearance of redness while defending against environmental stressors.

Developed by a dermatologist. Formulated by a scientist. Designed to support healthier-looking skin with every application.